A new 2025 prospective study shows that relying on an AP fluoroscopic view alone during lumbar interlaminar epidural steroid injections can lead to inaccurate interpretation of contrast spread. In this concise review, we break down the study’s key findings, compare AP versus contralateral oblique (CLO) imaging accuracy, and highlight why CLO provides a far more reliable confirmation of true epidural entry. A quick, evidence-based update for pain physicians looking to optimize their fluoroscopic technique.